Antimutagenic 1,4-Dihydropyridine AV-153 Normalizes Expression of GLUT1, GLUT4, INOS, PARP1, and Gamma H2AX Histone in Myocardium of Rats with Streptozotocin Model of Diabetes Mellitus

Abstract Diabetic cardiomyopathy increases the risk of heart failure and worsens prognosis for diabetes mellitus (DM) patients. Its development depends on many factors, including modification nitric oxide production impaired DNA repair. The goal present work was to study in vivo effects a 1,4-dihydropyridine AV-153, known as antimutagen DNA-binder, integrity, expression several proteins involved glucose transport, metabolism, repair myocardium diabetic rats. DM induced rats by streptozotocin (STZ) injection. Expression studied means immunohistochemistry. Development STZ-induced significantly PARP1 gamma H2AX histone, markers breakage, protein tissue, while AV-153 administration decreased expression. In this model diabetes, myocardial iNOS also increased, but reduced it normal levels. upregulated insulin-dependent GLUT4 insulin-independent GLUT1 transporters up level Thus, appears be prospective creation remedy prevention cardiomyopathy.